Endocrine Abstracts

ObjectiveThe aim of the study was to compare the effect of metformin, orlistat and pioglitazone on insulin resistance in patients with polycystic ovarian syndrome.Methods30 overweight PCOS women were recruited using the Rotterdam criteria (mean age (±S.E.M.) 26(±1.5)yrs and body mass index 35.9(±1.3) kg/m2). Fasting blood was collected at the same time each day on 10 c...

There has been controversy over the diagnostic utility of the LH/FSH ratio in polycystic ovarian syndrome, with more recent guidelines excluding it as a diagnostic test. However, LH/FSH is still often requested for that purpose and in our institution, 20% of the 12,000 annual requests for LH/FSH tests requested in a one year period had PCOS detailed on the card, at a cost of over £37,000.Objective: The aim of this study was to ascertain the biologi...

Natriuretic peptides BNP and NTpro-BNP have been suggested as being useful for the diagnosis of congestive heart failure, and have been shown to have excellent negative predictive value for excluding severe systolic left ventricular dysfunction.We have shown previously that changes in thyroid function are associated with changes in concentrations of other low molecular weight molecules through the changes on renal function. Therefore, the aim of this stu...

OBJECTIVE: To evaluate and compare the effect of treatment with orlistat versus metformin on the hormonal and biochemical features of patients with polycystic ovarian syndrome (PCOS)METHODS: 21 Caucasian women with PCOS (mean plus/minus SEM, age 27 plus/minus 0.9 years, and body mass index 36.7 plus/minus 3.3) participated in this prospective, randomised, open labelled, study. All subjects had an eight week run in period of dietary modification and then ...

Introduction: Reduced sex hormone binding globulin (SHBG) is seen in patients with polycystic ovarian syndrome (PCOS) and is considered a surrogate marker of hyperinsulinaemia in these patients. Little data currently exists on the biological variability of SHBG for an individual with PCOS and this information is crucial to establish its clinical utility. Method: 12 PCOS patients (median age 28 yrs, range 18-31) and 11 weight matched, control women having regular menses and wit...